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What drugs can cause a false positive for benzodiazepines? Doxylamine, found in Unisom and other over the counter sleep aids (similar to diphenhydramine), may cause a false positive on a drug test for methadone, opiates, and PCP. Sertraline (Zoloft) is an antidepressant and if you’ve taken it, you may test positive for benzodiazepines and LSD. You may also get a false positive if you take certain medicines for depression. These include tricyclic medicines, quetiapine, and bupropion. Talk with your healthcare provider about whether the prescription and over-the-counter drugs you take could cause a false positive test result.